Calcium-/Calmodulin-Dependent Protein Kinase II (CaMKII) Inhibition Induces Learning and Memory Impairment and Apoptosis

Figure 1

Global identification of target genes in primary cultured hippocampal neurons regulated by CaMKII inhibition. (a) Histogram indicating upregulated and downregulated genes. We observed 404 upregulated genes and 511 downregulated genes in KN93-treated neurons compared with untreated neurons. (b) Difference in gene expression levels in KN93-treated cultured neurons and untreated control groups according to the criteria and . The black dots between the two blue lines represent the downregulated genes after CaMKII inhibition, and the red dots on both sides of the blue line represent the upregulated genes. (c) Volcano plot of gene profiles in KN93-treated neurons compared with untreated neurons. Green and red plots represent genes that are abnormally expressed with and . Red and green plots indicate upregulated and downregulated genes. (d, e) GO analysis indicating differentially expressed genes between KN93-treated neurons and untreated control groups. The genes with higher expression in KN93-treated neurons compared with untreated control groups are shown in (d), while the lower expression genes are shown in (e). The arrows show the genes related to cognition, learning or memory, and long-term memory.

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