Panax Notoginseng Protects against Diabetes-Associated Endothelial Dysfunction: Comparison between Ethanolic Extract and Total Saponin

Figure 6

Vaso-protective effect of PNS and PNE in diet-induced obese (DIO) mice. (a) Changes in body weight in mice fed with high-fat or normal chow diet for 16 weeks and administered with vehicle (water), PNS, or PNE at 20 mg/kg body weight daily by oral gavage at the last 4 weeks. (b, c) Changes in systolic (SBP) and diastolic (DBP) blood pressure measured by tail-cuff method. (d) Changes in fast blood glucose (FBG) measured after fasting the mice for 6 h. (e) Oral glucose tolerance test (OGTT) upon 6-h fasting. (f) Insulin tolerance test (ITT) upon 2-h fasting. (g) Effect of oral administration of PNS or PNE (20 mg/kg/day, 4 weeks) on ACh-induced relaxations in aortas from DIO mice. (h) SNP-induced endothelium-independent relaxations in mouse aortas. (i) Changes in DHE intensity (oxidative stress indicator) in mouse aortas. Data are of 5 experiments. vs. control; vs. DIO.

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