Synthesis, Anticancer Assessment, and Molecular Docking of Novel Chalcone-Thienopyrimidine Derivatives in HepG2 and MCF-7 Cell Lines

Figure 14

Binding mode/interactions of 3g (shown as sticks colored by element) in Bcl-2: (a) 3D binding mode of 3g overlaid with the cocrystallized Pro (yellow sticks) into the active site of Bcl-2; (b) 2D binding mode of 3g showing different types of interactions with amino acids in Bcl-2.

(a)

(b)