Treatment of Radiation-Induced Brain Necrosis

Table 1

Recent reports on radiation-induced brain necrosis.

Authors (reference)	Disease	Total case	Year	RT dose (Gy)	Median follow-up time (mo)	RBN (no)	RBN (%)
Huang et al. [6]	NPC	6288	2019	67.4	12.5	24	0.4
Wang et al. [ 7]	NPC	749	2019	66-70.4	48.8	38	5.1
Lu et al. [8]	NPC	4186	2018	68-70	70	188	4.5
Li et al. [9]	NPC	1544	2017	2.0-2.48Gy/28-33 fr	79.7	2	0.13
Shen et al. [10]	NPC	106	2016	66-72	NR	78	73.6
Ilyas et al. [11]	AVM	13941	2018	NR	NR	1844	13.2
Cohen-Inbar et al. [12]	AVM	205	2017	10-50	69	73	35.6
Minniti et al. [13]	MBT	289	2016	3Gy/7 fr or 5Gy/5 fr	10	42	14.5
Swinson and Friedman [14]	MBT	619	2008	10-22.5	12.8	14	2.3
Ruben et al. [15]	Glioma	426	2006	>45 Gy/25 fr	>36	21	4.9

Abbreviations: RT: radiation; NR: not reported; Mo: months; NPC: nasopharyngeal carcinoma; RBN: radiation-induced brain necrosis; AVM: arteriovenous malformations; MBT: metastatic brain tumors.