The Relationship between Serum Trace Elements and Oxidative Stress of Patients with Different Types of Cancer

Table 6

The multinomial regression of TEs and OxS parameters in different cancers.

Cancer	Index	Crude			Adjusted
		OR(95% CI)	Wald		OR(95% CI)	Wald
Liver cancer	Cu	1.06(0.99, 1.12)	3.413	0.065	1.01(0.93, 1.10)	0.077	0.781
	Zn	1.03(0.98, 1.09)	1.380	0.240	1.07(0.98, 1.16)	2.430	0.119
	Fe	0.96(0.91, 1.01)	2.511	0.113	0.94(0.86, 1.02)	2.016	0.156
	Se	0.35(0.18, 0.57)	18.940	<0.001	0.39(0.17, 0.66)	13.361	<0.001
	TOS	1.22(1.11, 1.35)	16.758	<0.001	1.21(1.06, 1.38)	7.648	0.006
	TAS	0.47(0.11, 2.02)	1.027	0.311	0.40(0.05, 3.50)	0.684	0.408
	OSI	3.48(2.27, 5.35)	32.566	<0.001	1.54(0.89, 2.66)	2.396	0.122
Gastric carcinoma	Cu	0.95(0.89, 1.01)	3.195	0.074	0.94(0.88, 0.99)	4.025	0.045
	Zn	0.93(0.88, 0.98)	7.391	0.007	0.94(0.89, 1.01)	3.658	0.056
	Fe	0.86(0.81, 0.91)	25.315	<0.001	0.85(0.80, 0.92)	19.495	<0.001
	Se	1.11(0.66, 1.86)	0.147	0.701	1.28(0.74, 2.21)	0.754	0.385
	TOS	1.18(1.08, 1.29)	12.820	<0.001	1.19(1.07, 1.32)	10.179	0.001
	TAS	2.29(0.62, 8.54)	1.530	0.216	1.95(0.42, 9.03)	0.732	0.392
	OSI	7.45(4.92, 11.30)	89.644	<0.001	4.64(2.93, 7.32)	43.207	<0.001
Colorectal cancer	Cu	1.24(1.17, 1.32)	51.582	<0.001	1.29(1.15, 1.44)	20.029	<0.001
	Zn	0.80(0.76, 0.85)	49.473	<0.001	0.83(0.75, 0.92)	12.230	<0.001
	Fe	1.21(1.15, 1.27)	56.182	<0.001	1.18(1.07, 1.31)	10.547	0.001
	Se	0.64(0.35, 1.17)	2.078	0.149	1.06(0.36, 3.13)	0.010	0.921
	TOS	0.99(0.89, 1.10)	0.028	0.866	0.92(0.78, 1.09)	0.961	0.327
	TAS	0.35(0.08, 1.51)	1.980	0.159	0.40(0.03, 6.22)	0.425	0.515
	OSI	2.67(1.72, 4.15)	19.160	<0.001	1.04(0.66, 1.75)	0.305	0.581
Breast cancer	Cu	1.05(0.99, 1.11)	2.473	0.116	0.95(0.85, 1.05)	1.181	0.277
	Zn	0.79(0.74, 0.84)	61.402	<0.001	0.81(0.74, 0.89)	19.871	<0.001
	Fe	0.84(0.79, 0.89)	29.760	<0.001	0.83(0.75, 0.91)	13.515	<0.001
	Se	0.39(0.20, 0.55)	18.845	<0.001	0.53(0.22, 0.89)	4.753	0.029
	TOS	1.32(1.20, 1.46)	32.488	<0.001	1.34(1.17, 1.54)	17.573	<0.001
	TAS	0.52(0.12, 2.28)	0.742	0.389	0.22(0.02, 2.41)	1.547	0.214
	OSI	5.70(3.72, 8.72)	64.053	<0.001	2.56(1.48, 4.42)	11.377	<0.001
Lung cancer	Cu	1.05(0.99, 1.11)	2.450	0.117	0.95(0.86, 1.05)	1.092	0.296
	Zn	0.93(0.88, 0.98)	7.528	0.006	0.97(0.89, 1.06)	0.332	0.565
	Fe	0.82(0.77, 0.87)	41.438	<0.001	0.80(0.72, 0.88)	19.186	<0.001
	Se	0.26(0.13, 0.42)	45.183	<0.001	0.28(0.12, 0.44)	25.849	<0.001
	TOS	1.18(1.07, 1.29)	12.196	<0.001	1.19(1.04, 1.37)	6.717	0.010
	TAS	0.32(0.13, 0.55)	9.034	0.003	0.25(0.10, 0.49)	6.550	0.010
	OSI	7.08(4.67, 10.72)	85.428	<0.001	3.29(1.94, 5.58)	19.408	<0.001
Esophageal cancer	Cu	1.37(1.29, 1.46)	100.311	<0.001	1.44(1.29, 1.61)	41.301	<0.001
	Zn	0.89(0.85, 0.95)	14.667	<0.001	0.97(0.88, 1.06)	0.507	0.477
	Fe	1.09(1.04, 1.15)	12.382	<0.001	1.08(0.98, 1.19)	2.238	0.135
	Se	0.41(0.21, 0.59)	15.375	<0.001	0.46(0.19, 0.76)	6.115	0.013
	TOS	2.75(1.23, 5.54)	9.772	0.002	2.82(1.45, 6.49)	8.747	0.003
	TAS	1.11(1.01, 1.22)	4.350	0.037	0.97(0.83, 1.14)	0.131	0.718
	OSI	2.27(1.46, 3.54)	13.185	<0.001	1.06(0.76, 1.63)	1.705	0.192
Brain cancer	Cu	0.89(0.83, 0.95)	10.995	0.001	0.73(0.65, 0.82)	27.324	<0.001
	Zn	1.02(0.96, 1.08)	0.563	0.453	1.07(0.97, 1.18)	1.937	0.164
	Fe	0.71(0.65, 0.76)	73.692	<0.001	0.68(0.60, 0.77)	39.332	<0.001
	Se	0.22(0.11, 0.34)	60.802	<0.001	0.22(0.10, 0.36)	42.254	<0.001
	TOS	1.17(1.05, 1.30)	8.227	0.004	1.25(1.08, 1.44)	8.680	0.003
	TAS	0.22(0.10, 0.37)	17.296	<0.001	0.20(0.13, 0.32)	21.599	<0.001
	OSI	8.70(5.61, 13.50)	93.129	<0.001	4.70(2.70, 8.19)	29.917	<0.001
Kidney cancer	Cu	1.11(1.05, 1.17)	15.409	<0.001	1.10(1.05, 1.16)	15.717	<0.001
	Zn	0.92(0.88, 0.97)	11.220	0.001	0.91(0.87, 0.96)	11.094	0.001
	Fe	1.04(1.00, 1.09)	3.283	0.070	1.04(0.99, 1.09)	2.001	0.157
	Se	0.40(0.22, 0.54)	27.386	<0.001	0.45(0.25, 0.62)	28.107	<0.001
	TOS	1.08(0.99, 1.18)	2.871	0.090	1.06(0.97, 1.17)	1.666	0.197
	TAS	0.34(0.14, 0.59)	9.647	0.002	0.46(0.17, 0.72)	4.360	0.037
	OSI	3.59(2.39, 5.40)	37.702	<0.001	4.14(2.71, 6.32)	43.331	<0.001
Others	Cu	0.99(0.94, 1.05)	0.069	0.792	1.02(0.97, 1.07)	0.430	0.512
	Zn	1.01(0.96, 1.06)	0.158	0.691	1.00(0.95, 1.05)	0.016	0.899
	Fe	0.91(0.87, 0.96)	12.013	0.001	0.92(0.87, 0.97)	9.468	0.002
	Se	0.29(0.17, 0.50)	20.404	<0.001	0.34(0.20, 0.56)	17.572	<0.001
	TOS	1.06(0.97, 1.16)	1.488	0.223	1.03(0.94, 1.14)	0.403	0.526
	TAS	0.32(0.13, 0.60)	11.489	0.001	0.41(0.16, 0.74)	5.923	0.015
	OSI	4.61(3.04, 6.98)	52.138	<0.001	4.35(2.85, 6.65)	46.311	<0.001

Note: Adjusted by age and sex.