Identification of Sitogluside as a Potential Skin-Pigmentation-Reducing Agent through Network Pharmacology

Figure 2

The detailed analysis of key TCMs. (a) The ranking of 14 TCMs, according to the “average degree” of each TCM. (b) The Venn diagram on the potential active ingredients of FLL, HMM., AJ, PCSP, and PRA. (c) The KEGG target pathways of the top 20 enriched signaling pathways in the top 5 TCMs. (d–f) The disease-compound-target network between FLL, HMM, AJ, PCSP, PRA, and pigmentation, respectively. The network is composed of nodes and lines. Red node indicates diseases. Blue node indicates herbs. Yellow nodes indicate potential Chinese medicine activity components, and green nodes indicate related target genes. Lines indicate their interactions. ADBEH: A. dahurica (Fisch.) Benth. Et Hook; AJ: Ampelopsis japonica; ALD: Atractylodes lancea (Thunb.)Dc.; AMK: Atractylodes macrocephala Koidz.; BSRF: Bletilla striata (Thunb.Ex A.Murray) Rchb.F.; CS: Coicis Semen; FLL: Fructus Ligustri Lucidi; HMM: Hedysarum multijugum Maxim.; KEGG: Kyoto Encyclopedia of Genes and Genome; PCSP: Pseudobulbus Cremastrae Seu Pleiones; PCW: Poria Cocos (Schw.) Wolf.; PRA: Paeoniae Radix Alba; RS: Ricini Semen; TR: Typhonii Rhizoma; SMS: Sapindi Mukorossi Semen; TCM: traditional Chinese medicine.

(a)

(b)

(c)

(d)

(e)

(f)

(g)

(h)