Identification of Sitogluside as a Potential Skin-Pigmentation-Reducing Agent through Network Pharmacology

Figure 6

Sitogluside, the most common ingredient in the top five TCMs selected by network pharmacology, as small molecular compound of sterol, on the one hand, may reduce the expression of TYR by inhibiting the ERK and p38 pathway through binding to membrane receptors (such as OUR, MC1R, and C-KIT). On the other hand, it may penetrate the cell membrane, directly bind to tyrosinase, inhibit the activity of TYR, and reduce the melanin content. c-KIT: stem cell growth factor receptor; OUR: opioid u receptor; MC1R: melanocortin 1 receptor; TCM: traditional Chinese medicine; TYR: tyrosinase.