Colchicine vs. control; aspirin and rivaroxaban vs. control: (i) Composite of invasive mechanical ventilation or death (ii) Disease progression of 2 points on a 7-point scale Aspirin and rivaroxaban vs. control: (i) Composite of MACE (MI, stroke, acute limb ischemia, VTE, death)
UFH iv enoxaparin 1 mg/kg Clopidogrel 75 mg UFH sc Enoxaparin 40 mg/0.4 mL
Randomized, open label, factorial
750
Hierarchical composite: death due to venous or arterial thrombosis, pulmonary embolism, clinically evident DVT, type 1 MI, ischemic stroke, systemic embolism, or acute limb ischemia or clinically silent DVT
28
COVID-19: coronavirus disease 2019; DVT: deep vein thrombosis; ECMO: extra corporeal membrane oxygenation; ICU: intensive care unit; MACE: major adverse cardiovascular events; MI: myocardial infarction; P/F: PaO2/FiO2; RRT: renal replacement therapy; SARS-CoV2: severe acute respiratory syndrome coronavirus 2; UFH: unfractionated heparin; VTE: venous thromboembolism.