DCA Protects against Oxidation Injury Attributed to Cerebral Ischemia-Reperfusion by Regulating Glycolysis through PDK2-PDH-Nrf2 Axis
DCA improves mitochondrial metabolism after brain I/R injury. (a) Mitochondrial morphology was observed by electron microscopy 24 h after sham surgery or MCAO (). (b–e) Western blotting assay of key metabolic proteins PDK2 and PDH of mitochondrial TCA cycle in mouse brain as well as the band strength of the respective protein relative to Tubulin. (f, g) Effects of DCA on the contents of oxidative stress products SOD and MDA after brain I/R injury. and . The comparison between cohorts has been shown in the figure.
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