Association of NFE2L2 Gene Polymorphisms with Risk and Clinical Characteristics of Acute Type A Aortic Dissection in Han Chinese Population
Table 5
Association of rs2364723 and rs35652124 polymorphisms with AAAD clinical characteristics.
Variables
Overall
rs2364723
rs35652124
CC
GC or GG
CC
CT or TT
Number of patients
94
36
58
34
60
Demographics
Age (years)
0.865
0.762
Male, (%)
75 (80)
30 (83)
45 (78)
0.500
28 (82)
47 (78)
0.641
Medical histories, (%)
Hypertension
63 (67)
25 (69)
38 (66)
0.694
24 (71)
39 (65)
0.580
Diabetes
3 (3)
2 (6)
1 (2)
0.556
1 (3)
2 (3)
1.000
CKD
3 (3)
1 (3)
2 (3)
1.000
1 (3)
2 (3)
1.000
Prior aortic stent implant
3 (3)
1 (3)
2 (3)
1.000
1 (3)
2 (3)
1.000
Prior cardiac surgery
5 (5)
2 (6)
3 (5)
1.000
1 (3)
4 (7)
0.650
Smoking
38 (40)
16 (44)
22 (38)
0.532
15 (44)
23 (38)
0.583
Bicuspid aortic valve
7 (7)
5 (14)
2 (3)
0.102
5 (15)
2 (3)
0.094
Clinical presentation
Systolic blood pressure (mmHg)
0.817
0.870
Diastolic blood pressure (mmHg)
0.127
0.075
(mm)
45 (41-52)
49 (42-57)
42 (39-51)
0.002
49 (42-56)
43 (39-52)
0.011
Organ ischemia, (%)
Brain
3 (3)
3 (8)
0 (0)
0.053
3 (9)
0 (0)
0.045
Lower limb
15 (16)
8 (22)
7 (12)
0.191
6 (18)
9 (15)
0.736
Coronary artery involvement
18 (19)
11 (31)
7 (12)
0.027
10 (29)
8 (13)
0.057
Dissection characteristics
DeBakey classification, (%)
Type I
84 (89)
32 (89)
52 (90)
1.000
30 (88)
54 (90)
1.000
Type II
10 (11)
4 (11)
6 (10)
4 (12)
6 (10)
Primary entry site, (%)
Ascending aorta
62 (66)
26 (72)
36 (62)
0.600
25 (74)
37 (62)
0.490
Aortic arch
19 (20)
6 (17)
13 (22)
5 (15)
14 (23)
Descending aorta or unknown
13 (14)
4 (11)
9 (16)
4 (12)
9 (15)
Secondary entry site, (%)
None
76 (81)
29 (81)
47 (81)
1.000
28 (82)
48 (80)
0.948
Ascending aorta
2 (2)
1 (3)
1 (2)
1 (3)
1 (2)
Aortic arch
14 (15)
5 (14)
9 (16)
4 (12)
10 (17)
Descending aorta
2 (2)
1 (3)
1 (2)
1 (3)
1 (2)
Entry tears≥2, n (%)
18 (19)
7 (19)
11 (19)
0.954
6 (18)
12 (20)
0.781
Aortic valve regurgitation, (%)
None
14 (15)
4 (11)
10 (17)
0.298
3 (9)
11 (18)
0.205
Mild
36 (38)
14 (39)
22 (38)
13 (38)
23 (38)
Mild-moderate
11 (12)
3 (8)
8 (14)
3 (9)
8 (13)
Moderate
14 (15)
7 (19)
7 (12)
7 (21)
7 (12)
Moderate-severe
10 (11)
2 (6)
8 (14)
2 (6)
8 (13)
Severe
9 (10)
6 (17)
3 (5)
6 (18)
3 (5)
Laboratory tests on admission
WBC (109/L)
0.904
0.878
PLT (109/L)
156 (124-192)
155 (137-184)
157 (122-208)
0.800
154 (137-183)
157 (122-211)
0.620
Hb (g/L)
0.957
0.831
CRP (mg/L)
6.8 (2.4-20.3)
8.7 (2.7-19.2)
5.3 (2.3-22.1)
0.602
8.7 (2.7-21.3)
5.6 (2.3-20.9)
0.698
Fibrinogen (g/L)
2.13 (1.52-2.79)
2.36 (1.47-3.03)
1.95 (1.52-2.64)
0.621
2.31 (1.45-3.00)
1.96 (1.53-2.74)
0.953
D-dimer (μg/mL FEU)
10.9 (4.8-28.6)
8.9 (4.2-27.2)
12.0 (5.8-29.8)
0.283
9.6 (4.2-29.9)
11.4 (5.7-27.5)
0.544
UA (μmol/L)
0.574
0.831
Creatinine (μmol/L)
98 (76-127)
98 (78-129)
97 (74-127)
0.876
96 (77-124)
98 (75-128)
0.642
BUN (mmol/L)
6.78 (5.39-7.98)
6.56 (5.36-7.87)
6.91 (5.49-8.07)
0.735
6.56 (5.38-7.68)
6.91 (5.41-8.12)
0.645
Data are represented as the median (interquartile range), (%), or . CKD: chronic kidney disease; : maximum diameter of ascending aorta; WBC: white blood cell count; PLT: platelet; Hb: hemoglobin; UA: uric acid; BUN: blood urea nitrogen.
