The Antitriple Negative Breast cancer Efficacy of Spatholobus suberectus Dunn on ROS-Induced Noncanonical Inflammasome Pyroptotic Pathway

Figure 6

SSP promoted pyroptotic cell death in MDA-MB-231 cells. Bright field microscopic observation of (a, c) vehicle showed normal architecture of the cells. SEM observation (b, d) of SSP (100 μg/ml) in MDA-MB-231 cells exhibited flattened cells with the cabbage or fried egg-like the cell nucleus located in the center. Arrowhead indicated the bubbling of pyroptotic cells. Scale bar, 100 μm. (e, f) The release of LDH levels in BT-549 and MDA-MB-231 cell culture after 24 h treatment with SSP, respectively (100 μg/ml).

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