Pretreatment with 6-Gingerol Ameliorates Sepsis-Induced Immune Dysfunction by Regulating the Cytokine Balance and Reducing Lymphocyte Apoptosis

Figure 5

Administration of 6-gingerol increased neutrophil infiltration into BAL fluid and decreased neutrophil apoptosis. Mice were subjected to CLP and fed 6-gingerol as mentioned in the Materials and Methods. Survivors on Day 4 were secondarily challenged by intranasal instillation of P. aeruginosa (). (a) White blood cell numbers were assessed in BAL fluid 4 hours after instillation. (b–d) Neutrophil percent (b) and numbers (c), percent of apoptosis, and (d) IL-17 of BAL fluid sup (e) representative flow plots of CXCR2⁺ expression on neutrophils (left panels), percentage (middle panel), and numbers (right panel) (f) in BAL fluid were determined as described in Materials and Methods. Results are representative of three independent experiments and expressed as the . Statistically significant differences are shown on the graph.

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