Comparative Studies on the Hepatoprotective Effect of White and Coloured Rice Bran Oil against Acetaminophen-Induced Oxidative Stress in Mice through Antioxidant- and Xenobiotic-Metabolizing Systems

Figure 1

(a) The experimental protocol of RBO treatment in APAP-induced mice. Fasted male mice were orally administered with vehicle or 300 mg kg–1 BW of APAP. Three hours later, mice were administered with distilled water, WRBO, CRBO, or NAC and then euthanized six hours after APAP treatment. (b) Hepatic histomorphological changes in APAP-treated mice after RBO treatment by H&E staining under light microscopy. Micrographs are shown at 100x magnification. Arrows indicate necrotic areas. APAP: acetaminophen; WRBO: white rice bran oil 105; CRBO: coloured rice bran oil; NAC: -acetylcysteine.

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