Ameliorative Effect of Thymoquinone-Loaded PLGA Nanoparticles on Chronic Lung Injury Induced by Repetitive Intratracheal Instillation of Lipopolysaccharide in Rats

Figure 5

Representative electron micrograph of the lung of control rats showing normal ultrastructure (arrow) at 8 weeks and 10 weeks, TQ-PLGA NP group showing nearly normal pneumocytes nuclei with prominent vacuolated cytoplasm with a little lamellar material as well as nanomaterials (arrow) at 8 weeks and normal air-blood barrier with widening of blood capillary lumen which contain numerous erythrocytes (arrow) at 10 weeks, LPS-challenged rats showing diffuse loss of rough endoplasmic reticulum, mitochondria, blebbing of the nuclear membrane and glycogen lysis with destructed chromatin (arrows) at 8 and 10 weeks, and LPS + TQ-PLGA NPs showing some collagen fibers deposits besides vacuolated pneumocytes which contain nanomaterials (arrow) at 8 weeks, and prominent restoration of the ultrastructural features of the pneumocytes ultrastructure (arrow) at 10 weeks.