Research Article

Ketogenic Diet Suppressed T-Regulatory Cells and Promoted Cardiac Fibrosis via Reducing Mitochondria-Associated Membranes and Inhibiting Mitochondrial Function

Table 2

Metabolic indices of mice.

m/mdb/dbdb/db+KDdb/db+PBS value

Body weight (g)#<0.01
Heart weight (g)<0.01
Fasting glucose (mM)<0.01
TC (mg/dl)0.35
TG (mg/dl)§0.02
LDL-c (mg/ml)0.89
Fasting insulin (mIU/l)4#<0.01
HOMA-IR#<0.01

KD: ketogenic diet; PBS: phosphate-buffered solution; TC: total cholesterol; TG: triglyceride; LDL-c: low-density lipoprotein cholesterol; HOMA-IR: homeostasis model assessment-insulin resistance; compared with m/m, ; #compared with db/db+PBS, ; compared with db/db+PBS, ; §compared with db/db+PBS, ; values were derived from ANOVA.