Advances in Understanding Mitochondrial MicroRNAs (mitomiRs) on the Pathogenesis of Triple-Negative Breast Cancer (TNBC)

Figure 5

Schematic pipeline depicting mitomiRs that exert tumor-suppressive or tumor-promotive role on TNBC through acting on mechanisms involved in mtDNA maintenance or mitochondrial calcium uptake. Tumor-suppressive (blue rectangle) or tumor-promotive (pink rectangle) mitomiRs and their target genes (red). CX3CL1: C-X3-C motif chemokine ligand 1; CYP27B1: cytochrome P450 family 27, subfamily B, polypeptide 1; INSR: insulin receptor; IRS1: insulin receptor substrate 1; MCU: mitochondrial calcium uniporter; mtDNA: mitochondrial DNA; POLB: DNA polymerase beta; ROS: reactive oxygen species; TFAM: mitochondrial transcription factor A.