Advances in Understanding Mitochondrial MicroRNAs (mitomiRs) on the Pathogenesis of Triple-Negative Breast Cancer (TNBC)

Table 5

Clinicopathological relevance of mitomiRs.

mitomiRs	Specimen	Expression	Clinical relevance	PMID	Reference
miR-4488	Serum EVs	↓	Low expression in TNBC patients	33067576	Zheng et al., 2020 [74]
miR-21	Serum	↓	Decreased level in BC patients after metformin treatment	28698800	Pulito et al., 2017 [48]
miR-34a	Serum; Tissue	↓	Low expression predicts poor OS of TNBC patients	31616515; 31897330	Li et al., 2019 [47]; Kim et al., 2019 [77]
miR-29a	Tissue	↓	Low expression predicts poor OS of BC patients	33223849	Wang et al., 2020 [28]
miR-1	Tissue	↓	Low expression in BC patients	31765945	Zhang et al., 2019 [71]
miR-324	Tissue	↓	Low expression correlated with large tumor size and advanced TNM stage (III-IV) of BC patients	31751910	Zhang et al., 2019 [52]
miR-342	Tissue	↓	Low expression predicts poor OS of TNBC patients	30115973	Romero-Cordoba et al., 2018 [34]
miR-128	Tissue	↓	Low expression predicts poor OS and DFS of TNBC patients	29116653	Xiao et al., 2018 [33]
miR-125b	Tissue	↓	Low expression in BC tissue and TNBC cell line	29434858	Hu et al., 2018
miR-4485	Tissue	↓	Low expression in BC patients	28220193	Sripada et al., 2017 [44]
miR-663	Tissue	↓	Low expression predicts poor OS of BC patients	29066618	Carden et al., 2017 [45]
miR-195	Tissue	↓	Low expression in TNBC patients	29183284	Qattan et al., 2017 [79]
miR-148a, miR-152	Tissue	↓	Low expression in TNBC tissue compared to adjacent normal tissue	25703326	Xu et al., 2015 [46]
miR-101	Tissue	↓	Low expression associated with advanced TNM stage (III-IV) and lymph node infiltration of TNBC patients	26036638	Liu et al., 2015 [55]
miR-195	Plasma	↑	High expression in TNBC patients	29183284	Qattan et al., 2017 [79]
miR-210	Plasma	↑	High expression in TNBC patients	29183284	Qattan et al., 2017 [79]
miR-16	Plasma	↑	High expression in TNBC patients	29183284	Qattan et al., 2017 [79]
miR-221	Serum; Tissue	↑	High expression in serum and tumor tissue of BC patients	26503209	Ye et al., 2016 [80]
miR-27a	Serum	↑	High expression in BC patients and in TNBC cell line	26662313	Zhou et al., 2016 [81]
miR-155	Tissue	↑	High expression in tumor tissue indicates elevated glucose uptake of TNBC patients	29527004	Kim et al., 2018 [32]
miR-210	Tissue	↑	High expression in TNBC patients	29183284	Qattan et al., 2017 [79]
miR-16	Tissue	↑	High expression in TNBC patients	29183284	Qattan et al., 2017 [79]
miR-373	Tissue	↑	High expression predicts lymph node metastasis of BC patients	26196741	Chen et al., 2015 [53]

“↑”: enhanced; “↓”: reduced; BC: breast cancer; DFS: disease-free survival; EVs: extracellular vesicles; OS: overall survival; TNBC: triple-negative breast cancer; TNM: tumor, node, metastasis.