Advances in Understanding Mitochondrial MicroRNAs (mitomiRs) on the Pathogenesis of Triple-Negative Breast Cancer (TNBC)

Table 6

mitomiR-based therapeutics and targeting mechanisms in preclinical study of TNBC.

Approach/reagent	Effecting mitomiR	Experimental model	PMID	Reference
Metabolic reprogramming
siRNA-circPVT1	↑miR-29a	In vivo, in vitro	33223849	Wang et al., 2020 [28]
Lentivirus-miR-128	↑miR-128	In vivo, in vitro	29116653	Xiao et al., 2018 [33]
Small molecule (metformin)	↓miR-21	In vitro, in vivo	28698800	Pulito et al., 2017 [48]
Apoptosis
Nanoparticle-loaded miR-34a	↑miR-34a	In vivo, ex ovo, in vitro	32319481	Ahir et al., 2020 [54]
Nanoparticle-loaded anti-miR-10b	↓miR-10b	In vivo, ex ovo, in vitro	32319481	Ahir et al., 2020 [54]
Cisplatin+thiosemicarbazone compound 4	↑miR-125a, ↑miR-181a	In vitro	31541355	Majzoub et al., 2019
shRNA-lncCAMTA1	↑miR-20b	In vitro	28550685	Lu et al., 2018 [59]
Anti-miR-221	↓miR-221	In vitro	26503209	Ye et al., 2016 [80]
Redox signaling
Natural product (ursolic acid)	↓miR-499a	Ex ovo, in vitro	33278391	Manda et al., 2020 [76]
Physical agent (ultrasound)	↑miR-200c	In vitro	32313093	Shi et al., 2020 [85]
Natural product (parthenolide)	↑miR-29b	In vitro	31313842	De Blasio, 2019 [84]
shRNA-LINC00963	↑miR-324	In vitro, in vivo	31751910	Zhang et al., 2019 [52]
Adenovirus-MDA-7	↓miR-221	In vitro, in vivo	30842276	Pradhan et al., 2019 [82]
CuO-Nw-FA	↑miR-425	In vivo, ex ovo, in vitro	26520043	Ahir et al., 2016 [83]
Histone deacetylase inhibitor (SAHA)	↑miR-200a	In vitro	21926171	Eades et al., 2011 [51]
Mitochondrial calcium transport
Exosome	↑miR-4488	In vivo, in vitro	33067576	Zheng et al., 2020 [74]

“↑”: enhanced; “↓”: reduced; circPVT1: circular RNA PVT1; CuO-Nw-FA: copper oxide nanowire conjugated with folic acid; lncRNA: long noncoding RNA; MITF: melanogenesis-associated transcription factor; SAHA: suberoylanilide hydroxamic acid.