Review Article
Advances in Understanding Mitochondrial MicroRNAs (mitomiRs) on the Pathogenesis of Triple-Negative Breast Cancer (TNBC)
Table 7
Interventional clinical trials for mitomiRs.
| | Intervention | Effecting mitomiR | Cancer type | Trial number | Phase (status) |
| | Metabolic reprogramming | | Cobomarsen (MRG-106) | ↓miR-155 | T-cell lymphoma/mycosis fungoides | NCT03713320; NCT03837457 | Phase 2 (terminated) | | TargomiRs | ↑miR-16 | Mesothelioma
NSCLC | NCT02369198 | Phase 1 (completed) | | Apoptosis | | MRX-34 | ↑miR-34a | Liver cancer | NCT01829971 | Phase 1 (terminated) | | Lymphoma | | SCLC | | NSCLC | | Melanoma | | Multiple myeloma | | Renal cell carcinoma |
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“↑”: enhanced; “↓”: reduced; NSCLC: non-small-cell lung cancer; SCLC: small cell lung cancer.
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