Bacteriocins: Potential for Human Health

Table 2

Anticancer effects of bacteriocins.

Bacteriocins	Classification	Source	Target cancer cells (mechanism) or effects in vivo
Nisin	Lanthipeptide	L. lactis	SW1088 [57]; HNSCC (arresting the cell cycles) [53]; SW480 (increasing the apoptosis index of bax/bcl-2) [54]; LS180, HT29, and Caco2 (decreasing the expression of genes related to proliferation and migration) [55]. IMR-32 (enhancing cell membrane fluidity) [59]. Combining with doxorubicin can reduce the tumor volume of skin cancer in mice [60]. Decreasing the IC50 of 5-FU on A431 cells and promote the elimination of tumors in mice [61, 153]
Nisin Z	Lanthipeptide	L. lactis	A375 (inducing cell membrane damage, increasing ROS accumulation, inhibiting mitochondrial respiration and glycolytic metabolism) [58]; HNSCC (induces apoptosis and reduces proliferation and clone formation). Reduces the occurrence of tumors in mice and prolongs survival [154]
Bovicin HC5	Lanthipeptide	S. bovis HC5	MCF-7 and HepG2 [155]
Duramycin	Lanthipeptide	S. griseoverticillatum	MCA-RH 7777 (enhancing the sensitization) [67]
Chaxapeptin	Lasso peptide	S. leeuwenhoekii C58	A549 [66]
Thiostrepton	Thiopeptide	S. aureus	MCF-7 (inhibiting FOXM1expression) [68, 69]. Inhibiting endometriosis lesions and reducing the levels of MMP9 and bcl-2 in rats [70]
Microcin E492	Microcin	K. pneumoniae	HeLa, Jurkat, and Ramos (forming ion channels) [63]. Tumor inhibition in SW480 and SW620 zebrafish xenograft models [156]
Pediocin CP2	Class IIa	P. acidacticactic CP2	MCF-7, HepG2, Sp2/0-Ag14 and HeLa (affecting cell division and DNA synthesis) [64]
Pediocin PA-1	Class IIa	P. acidilactici K2a2-3	HT29 and HeLa [24]
Plantaricin A	Class IId	L. Plantarum	Jurka (disrupting cell membrane structure) [65]
Laterosporulin 10	Class IId	B. laterosporus SKDU10	MCF-7, HEK293T, HT1080, HeLa and H1299 (disrupting cell membrane structure) [62]