Bu Shen Yi Sui Capsule Alleviates Neuroinflammation and Demyelination by Promoting Microglia toward M2 Polarization, Which Correlates with Changes in miR-124 and miR-155 in Experimental Autoimmune Encephalomyelitis

Figure 2

BSYS suppressed inflammatory cell infiltration and promoted myelination in EAE mice. (a) Inflammatory infiltrates of the SVZ and LE of mice in each group were observed by H&E staining. Scale bars: 100 μm. (b) Demyelination of the SVZ and LE of mice in each group was observed by LFB staining. Scale bars: 100 μm. (c) Myelin ultrastructure of the SVZ and LE of mice in each group was observed by TEM. Scale bars: 2 μm. (d, e) Histological quantification of H&E-stained sections in each group. (f, g) Histological quantification of LFB-stained sections in each group. (h, i) G-ratio of axons in spinal cords from mice in each group at day 40. Data are presented as ; compared with the NC group, ^##; compared with the EAE group, , .

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