Bu Shen Yi Sui Capsule Alleviates Neuroinflammation and Demyelination by Promoting Microglia toward M2 Polarization, Which Correlates with Changes in miR-124 and miR-155 in Experimental Autoimmune Encephalomyelitis

Figure 3

BSYS promoted the maturation of oligodendrocytes in EAE mice. (a) Immunofluorescence of SVZ from mice in each group using antibodies against Olig2 (green) and CC-1 (red). Scale bars: 100 μm. (b) Quantification of Olig2+ cells density in SVZ. (c) Quantification of the percentage of CC-1+/Olig2+ cells in LE. (d) Immunofluorescence of LE using antibodies against Olig2 and CC-1. Scale bars: 100 μm. (e) Quantification of Olig2+ cells density in LE. (f) Quantification of the percentage of CC-1+/Olig2+ cells in LE. (g) The expression of PLP in SVZ and LE was detected by immunohistochemistry. Scale bars: 100 μm. (h, i) Percentage of MBP covered area in the SVZ and LE. Data are presented as ; compared with the NC group, ^##; compared with the EAE group, , .

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