Role of RONS and eIFs in Cancer Progression

Figure 1

A schematic presentation of RONS levels in the cell and their impact, the reasonable amounts of RONS are a key player for activating protective signaling pathways whereas elevated RONS is considered lethal to most cellular functions and may lead to cancer development. RONS: reactive oxygen and nitrogen species; P53: tumor suppressor; JNK: Jun N-terminal kinase.