Role of RONS and eIFs in Cancer Progression

Table 2

Dysregulated eIFs in different types of cancer.

Protein	Form of dysregulation	Resultant cancer	Refs.
eIF1	Overexpression	HCC	[104]
	Mutation	Thyroid cancer	[105]
eIF2 alpha	Increased Phosphorylation	Oropharyngeal	[95]
	Overexpression	Gastrointestinal	[106]
		NSCL	[107]
		Lymphoma	[23]
		Brain tumor	[108]
		Thyroid carcinoma	[109]
eIF3A	Overexpression	Colorectal	[110]
eIF3B		Esophageal	[111]
eIF3C		Glioma	[112]
eIF3D		Breast	[92]
		Prostate	[93]
		Gastric	[113]
eIF3H		HCC	[114]
eIF3I		Head and neck	[115]
eIF3M		Colorectal	[116]
eIF3E	Downregulation	Breast	[23]
eIF3F		Pancreatic	[117]
eIF4E	Overexpression	Brain	[108]
		Endometrial	[118]
		Head and neck	[119]
		Bladder	[120]
		Cervical	[121]
		Prostate	[122]
		Colon	[123]
		Liver	[124]
		Lymphoma	[125]
		Esophagus	[126]
		Gastric	[127]
eIF4G		Nasopharyngeal	[128]
		Breast	[80, 129]
		Squamous cell lung cancer	[130]
		Cervical cancer	[81]
		Melanoma	[131]
eIF4A	Downregulation	Breast	[132]
		Lung	[133]
eIF4B	Overexpression	B-cell lymphoma	[134]
eIF4H		Lung	[135]
eIF5	Overexpression	HCC	[136]
		Glioblastoma	[137]
		Lung	[138]
		Urinary bladder	[139]
		Ovarian	[140]
		Colorectal	[141]
eIF6	Overexpression	Leukemia	[142]
		Ovarian serous	[143]

HCC: hepatocellular carcinoma; NSCL: non-small-cell lung cancer.