Role of SIRT1 in Hepatic Encephalopathy: In Vivo and In Vitro Studies Focusing on the NLRP3 Inflammasome

Figure 12

A schematic showing the protective effect of CAY10602 on microglia and neuronal cells. The activation of NLRP3 inflammasome complex involves two signals: LPS and ATP. LPS and ATP stimulation results in the formation of NLRP3 inflammasomes and ROS accumulation. CAY10602 alleviates the activation of NLRP3 inflammasome and ROS in BV2 microglia cells. CAY10602 alleviates the neurotoxicity of ammonia on HT22 neuronal cells.