Hypoxia and the Kynurenine Pathway: Implications and Therapeutic Prospects in Alzheimer’s Disease

Figure 2

Schematic diagram showing some contributory factors to the pathology of AD. The mechanism by which amyloid-beta and neurofibrillary tangles are deposited in the brain to cause neuronal loss is unknown. Several hypotheses postulate neuronal loss in AD; however, amyloid-beta accumulation in the brain triggers a series of complex reactions that result in neuronal loss. Affected regions of the brain demonstrate inflammation, amyloid plaques, and neurofibrillary tangles.