Probiotics Fermentation Technology, a Novel Kefir Product, Ameliorates Cognitive Impairment in Streptozotocin-Induced Sporadic Alzheimer’s Disease in Mice

Figure 10

Congo red stained brain sections of mice for amyloid plaques visualization. Sham control group (a, g) showed no deposition of amyloid plaques (magnification ×20 and ×10, respectively). STZ group (b, h) showed diffuse deposition in the cerebral cortex and multifocal deposition in the hippocampus (arrows), respectively (magnification ×20). STZ + simvastatin (c, i) displayed minute deposition of amyloid plaques (magnification ×20 and ×10, respectively). PFT (100 mg/kg) (d, j) revealed multifocal scattered plaques (arrows). PFT (300 mg/kg) (e, k) presented multifocal area in the cerebral cortex and few depositions in the hippocampus (magnification ×20). PFT (600 mg/kg) (f, l) exhibited minute deposition of amyloid plaques (magnification ×20 and ×10, respectively).