Probiotics Fermentation Technology, a Novel Kefir Product, Ameliorates Cognitive Impairment in Streptozotocin-Induced Sporadic Alzheimer’s Disease in Mice

Table 2

The survival rate percent of intact neurons in the cerebral cortex, different hippocampal regions and amyloid plaques recorded in the brain of the mice.

Groups	Survival rate percent of intact neurons				Amyloid plaques
	Cerebral cortex	CA3	CA4	DG	Cerebral cortex + hippocampus
Sham control	95.3 ± 1.5	92.3 ± 1.5	89.0 ± 1.0	92.3 ± 1.5	—
STZ model	44.7 ±2.1	27.3 ± 1.5	31.0 ± 1.0	36.0 ± 1.0	12 (10-18)
STZ + simvastatin	89.0 ± 1.0^####	82.3 ± 1.5^####	71.0 ± 1.0^####	81.0 ± 1.0^####	2.5 (0-5)^##
STZ+ PFT (100 mg/kg)	73.3 ± 1.5^####	77.7 ±2.1^####	60.7 ± 1.5^####	71.7 ± 1.5^####	3 (2-6)^#
STZ+ PFT (300 mg/kg)	83.0 ±2.0^####	81.0 ± 1.0^####	66.3 ± 1.5^####	71.7 ± 1.5^####	3 (1-5)^#
STZ+ PFT (600 mg/kg)	85.7 ± 1.5^####	85.7 ± 4.7^####	77.3 ± 1.5^####	80.7 ± 1.5^####	2.5 (0-4)^###

Data of survival rate percent of intact neurons represents the mean ± SD of 3 mice per group and data of amyloid plaques represents the median and range of 3 mice per group; significantly different from sham control group at p <0.05, significantly different from sham control group at p <0.01, significantly different from sham control group at p <0.001, significantly different from sham control group at p <0.0001, #significantly different from STZ group at p <0.05, ## significantly different from STZ group at p <0.01, ### significantly different from STZ group at p <0.001, #### significantly different from STZ group at p <0.0001 using one-way ANOVA followed by Tukey’s multiple comparisons test for statistical analysis of survival rate, and using Kruskal–Wallis one-way ANOVA followed by Dunn’s multiple comparisons test for statistical analysis of amyloid plaque number.