Protective Effect of Penetratin Analogue-Tagged SOD1 on Cisplatin-Induced Nephrotoxicity through Inhibiting Oxidative Stress and JNK/p38 MAPK Signaling Pathway

Figure 6

PSF-SOD1 inhibits CP-induced ROS production and JNK/p38 MAPK pathway activation. VERO cells were pretreated with PSF-SOD1, TAT-SOD1, and SOD1 for 1 h and then exposed to CP. (a) Images were acquired using a fluorescence microscope. (b) ROS-positive cells were quantified using flow cytometry. (c, d) Western blot analysis was performed using antibodies against p-JNK, p-ERK, and p-p38. ^## and ^### compared with control cells. , , compared with the cells exposed to CP. ^$ compared with TAT-SOD1-treated cells.

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