Rosiglitazone Suppresses Renal Crystal Deposition by Ameliorating Tubular Injury Resulted from Oxidative Stress and Inflammatory Response via Promoting the Nrf2/HO-1 Pathway and Shifting Macrophage Polarization

<div>ROSI inhibited renal oxidative stress in the mouse model. (a) Immunohistochemical distribution of gene expression of Nrf2, HO-1, and SOD1 in the kidneys (arrows). 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(c) The expression of PPAR<i>γ</i>, Nrf2, HO-1, and SOD1 in kidney tissues by Western blotting. (d) ROS, H<sub>2</sub>O<sub>2</sub>, MDA, and GSH levels in mouse renal tissues. 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Oxidative Medicine and Cellular Longevity

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Figure 3

Figure 3: Rosiglitazone Suppresses Renal Crystal Deposition by Ameliorating Tubular Injury Resulted from Oxidative Stress and Inflammatory Response via Promoting the Nrf2/HO-1 Pathway and Shifting Macrophage Polarization 

Figure 3 | Rosiglitazone Suppresses Renal Crystal Deposition by Ameliorating Tubular Injury Resulted from Oxidative Stress and Inflammatory Response via Promoting the Nrf2/HO-1 Pathway and Shifting Macrophage Polarization 