Research Article
Wogonin Strengthens the Therapeutic Effects of Mesenchymal Stem Cells in DSS-Induced Colitis via Promoting IL-10 Production
Table 1
The division animal groups and the histological scoring system.
| | Animal groups | Tissue inflammation | Extent | Regeneration | Crypt damage | Percentage involvement | Histological score |
| | Control/ | None | None | Complete regeneration or normal tissue | None | — | 0 | | IBD/ | Slight | Mucosa | Almost complete regeneration | Basal 1/3 damaged | 1%–25% | 1 | | MSCs/ | Moderate | Mucosa and submucosa | Regeneration with crypt’s depletion | Basal 2/3 damaged | 26%–50% | 2 | | Wogonin/ | Severe | Transmural | Surface epithelium not intact | Only surface epithelium intact | 51%–75% | 3 | | Wogonin+MSCs | — | — | No tissue repair | Entire crypt and epithelium lost | 76%–100% | 4 |
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