Review Article
The Controversial Role of Glucose-6-Phosphate Dehydrogenase Deficiency on Cardiovascular Disease: A Narrative Review
Table 1
Most common mutations causing G6PD deficiency worldwide.
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
A lower level of enzyme activity in the erythrocytes of genetically deficient individuals might be due to a normal rate of synthesis of an enzyme of low catalytic efficiency, a decreased rate of synthesis of a normally active enzyme, an increased lability of the variant enzyme or a combined mechanism. The clinical phenotype depends on the mutation location in the 3D structure of the protein. G6PD A– is a more labile enzyme with normal rate of synthesis. |