Exosomal miR-218-5p/miR-363-3p from Endothelial Progenitor Cells Ameliorate Myocardial Infarction by Targeting the p53/JMY Signaling Pathway

Figure 1

Differential miRNA expression profiles between EPCs and EPC-Exos. (a) Hierarchical clustering of differentially expressed miRNAs between EPCs and EPC-Exos, which are displayed on a scale from green (low) to red (high). (b) Hierarchical clustering heat map of the clearly distinct differentially expressed miRNAs in EPCs and EPC-Exos, ranging from red (relatively high miRNA expression) to blue (relatively low miRNA expression). The miRNAs in the heat map are clustered based on the relative expression patterns. (c) The relative expression levels of sixteen differentially expressed miRNAs (eight upregulated and eight downregulated) in EPC-Exos compared with EPCs were measured with qRT-PCR. The data are presented as the (). , , and , EPC-Exos versus EPCs.

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