Exosomal miR-218-5p/miR-363-3p from Endothelial Progenitor Cells Ameliorate Myocardial Infarction by Targeting the p53/JMY Signaling Pathway

Figure 2

miR-218-5p and miR-363-3p promoted angiogenesis and proliferation of CFs. (a) The relative expression levels of miR-6087, miR-218-5p, and miR-363-3p mimics and inhibitors were measured with qRT-PCR. The data are presented as the (). and , mimic-Exo or inhibitor-Exo versus NC-Exo. (b) Tube formation capability and relative tube length were increased in the miR-218-5p and miR-363-3p mimic-Exo groups and decreased in inhibitor-Exo groups. The data are presented as the (). and , mimic-Exo or inhibitor-Exo versus NC-Exo. (c) CCK8 assay to detect the effect of exosomal miR-218-5p and miR-363-3p on cell proliferation. The data are presented as the (). and , mimic-Exo or inhibitor-Exo versus NC-Exo. (d) BrdU labelling and flow cytometry assay to detect the effect of exosomal miR-218-5p and miR-363-3p on cell proliferation. The data are presented as the (). and , mimic-Exo or inhibitor-Exo versus NC-Exo.

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