Exosomal miR-218-5p/miR-363-3p from Endothelial Progenitor Cells Ameliorate Myocardial Infarction by Targeting the p53/JMY Signaling Pathway

Figure 3

miR-218-5p and miR-363-3p promoted mesenchymal-endothelial transition in CFs. (a) A phagocytosis assay was performed to detect the engulfment of Dil-Ac-LDL and binding to endothelial-specific lectin FITC-UEA-1 by CFs treated with mimic-218-Exo or inhibitor-218-Exo. Magnification: 120x. (b) A phagocytosis assay was performed to detect the engulfment of Dil-Ac-LDL and binding to endothelial-specific lectin FITC-UEA-1 by CFs treated with mimic-363-Exo or inhibitor-363-Exo. Magnification: 120x. (c) qRT-PCR detection of the relative expression levels of CD31, VEGFR-2, α-SMA, and vimentin in CFs treated with mimic-218-Exo or inhibitor-218-Exo. The data are presented as the (). and , mimic-Exo or inhibitor-Exo versus NC-Exo. (d) qRT-PCR detection of the relative expression levels of CD31, VEGFR-2, α-SMA, and vimentin in CFs treated with mimic-363-Exo or inhibitor-363-Exo. The data are presented as the (). , , and , mimic-Exo or inhibitor-Exo versus NC-Exo.

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