Exosomal miR-218-5p/miR-363-3p from Endothelial Progenitor Cells Ameliorate Myocardial Infarction by Targeting the p53/JMY Signaling Pathway

Figure 8

Effect of exosomal miR-218-5p and miR-363-3p on cardiac features and function in MI rats. (a) A representative ECG of LCA-induced MI rats in the different groups (sham, model, miR-218-5p, and miR-363-3p mimic-Exo). (b) TTC staining of heart tissues from the sham, model, and mimic-Exo groups. The data are presented as the (). and , mimic-Exo versus model. (c, d) qRT-PCR to detect the relative expression levels of miR-218-5p, miR-363-3p, p53, and JMY in the mimic-Exo groups. (e) The protein expression of p53, JMY, collagen-1/3, and Timp-1-4 in the different groups. The data are presented as the (). and , mimic-Exo versus model.

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