Research Article
Mitochondrial Dysfunction Contributes to Aging-Related Atrial Fibrillation
Table 3
Logistic regression analysis for the presence of AF.
| | Simple regression | Multiple regression | | OR (95% CI) | value | OR (95% CI) | value |
| | Clinical parameters | | Age (years) | 1.006 (0.982-1.031) | 0.627 | | | | BMI (kg/m2) | 1.089 (0.982-1.207) | 0.107 | | | | Smoking, (%) | 0.714 (0.347-1.471) | 0.361 | | | | History of CHD, (%) | 0.824 (0.407-1.668) | 0.591 | | | | Hypertension, (%) | 1.233 (0.699-2.177) | 0.470 | | | | Diabetes mellitus, (%) | 1.162 (0.543-2.486) | 0.699 | | | | Hyperlipidemia | 0.789 (0.402-1.551) | 0.493 | | | | Antihypertensive medication, (%) | 1.183 (0.670-2.088) | 0.562 | | | | Glucose lowering treatment, (%) | 1.085 (0.492-2.391) | 0.840 | | | | Lipid-lowering medication, (%) | 0.736 (0.411-1.316) | 0.301 | | | | SBP (mmHg) | 1.011 (1.008-1.061) | 0.380 | | | | DBP (mmHg) | 1.027 (0.994-1.061) | 0.110 | | | | Laboratory parameters | | TC (mmol/L) | 0.864 (0.584-1.277) | 0.462 | | | | TG (mmol/L) | 1.562 (0.904-2.700) | 0.110 | | | | LDL-C (mmol/L) | 0.780 (0.517-1.176) | 0.236 | | | | HDL-C (mmol/L) | 0.607 (0.244-1.509) | 0.282 | | | | Cr (mmol/L) | 1.015 (0.998-1.031) | 0.084 | | | | BUN (mmol/L) | 1.095 (0.923-1.298) | 0.300 | | | | UA (mmol/L) | 1.005 (1.001-1.009) | 0.027 | 1.004 (0.999-1.009) | 0.130 | | FBG (mmol/L) | 0.968 (0.723-1.296) | 0.828 | | | | GHb (%) | 1.272 (0.798-2.026) | 0.311 | | | | CRP (mg/dL) | 2.250 (1.277-3.965) | 0.005 | 1.971 (1.023-3.799) | 0.043 | | Echocardiographic parameters | | LVEF (%) | 0.933 (0.869-1.002) | 0.058 | | | | LAD (mm) | 1.095 (1.009-1.187) | 0.030 | 1.084 (0.984-1.195) | 0.103 | | Telomere-associated molecules | | LTL ( ratio) | 0.388 (0.269-0.560) | <0.001 | 0.404 (0.278-0.587) | <0.001 | | Leukocyte p53 mRNA | 2.340 (0.848-6.457) | 0.101 | | | | Leukocyte PGC-1α mRNA | 2.340 (0.848-6.457) | 0.101 | | | | Serum PGC-1α(pg/mL) | 0.994 (0.991-0.998) | 0.001 | 0.994 (0.989-0.998) | 0.003 |
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Abbreviations: CI: confidence interval; BMI: body mass index; CHD: coronary heart disease; SBP: systolic blood pressure; DBP: diastolic blood pressure; TC: total cholesterol; TG: triglyceride; LDL-C: low-density lipoprotein cholesterol; HDL-C: high-density lipoprotein cholesterol; Cr: creatinine; BUN: blood urea nitrogen; UA: uric acid; FBG: fasting blood glucose; GHb: glycated hemoglobin; CRP: C-reactive protein; LVEF: left ventricular ejection fraction; LAD: left atrial diameter; ratio: the ratio of telomere repeats to single-copy gene copies; PGC-1 α: peroxisome proliferator-activated receptor γ coactivator-1 α. with italic font means statistically significant. |
