A Novel Ruthenium-Fluvastatin Complex Downregulates SNCG Expression to Modulate Breast Carcinoma Cell Proliferation and Apoptosis via Activating the PI3K/Akt/mTOR/VEGF/MMP9 Pathway

Figure 7

(a) Clonogenic assay of MCF-7 and MDA-MB-231 cells after 24 hours of treatment with the ruthenium-fluvastatin complex. (b) Quantification of the colony number for MCF-7 cells. (c) Quantification of colony size of the clonogenic assay of MCF-7 cells. (d) Plating efficiency for the clonogenic assay of MCF-7 cells. (e) Quantification of the colony number for MDA-MB-231 cells. (f) Quantification of colony size for MDA-MB-231 cells. (g) Plating efficiency for the clonogenic assay of MDA-MB-231 cells. Quantification of the colony number and size was performed using the ImageJ public domain software. Data represent from three different experiments in triplicate. The results were compared using ANOVA, followed by Tukey’s post hoc analysis. Asterisks represent , , and as compared to carcinogen control.

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