A Novel Ruthenium-Fluvastatin Complex Downregulates SNCG Expression to Modulate Breast Carcinoma Cell Proliferation and Apoptosis via Activating the PI3K/Akt/mTOR/VEGF/MMP9 Pathway

Table 8

Cell proliferation and apoptosis in the breast.

Groups	Ki-67-LI^§	AI (%)^§
Normal control
DMBA
Ru-flu 25 mg/kg
Ru-flu 50 mg/kg		^##	^$$
Ru-flu 75 mg/kg		^#	^$
Ru 50 mg/kg
Flu 50 mg/kg

LI = labeling index; Ki-67-LI = percentage of PCNA-labeled cells/total number of cells counted; AI = apoptotic index. . AI was calculated as the percentage of TUNEL-positive cells/total number of cells counted. Values represent . ^§A total number of six slides were evaluated per rat. Each field consisted of approximately 500 cells. Significant difference between Ki-67-LI of Ru-flu 75 mg/kg and carcinogen control animals (). Significant difference between Ki-67-LI of Ru 50 mg/kg, Ru-flu 50 mg/kg, and carcinogen control animals (). ^#Significant difference between AI of Ru-flu 75 mg/kg and carcinogen control (). ^##Significant difference between AI of Ru 50 mg/kg, Ru-flu 50 mg/kg, and carcinogen control animals (). ^$Significant difference between of Ru-flu 75 mg/kg and carcinogen control animals (). ^$$Significant difference between R of Ru 50 mg/kg, Ru-flu 50 mg/kg, and carcinogen control animals ().