Research Article
Exosomal MATN3 of Urine-Derived Stem Cells Ameliorates Intervertebral Disc Degeneration by Antisenescence Effects and Promotes NPC Proliferation and ECM Synthesis by Activating TGF-β
Figure 7
MATN3 of USC-exos mediated the antisenescence and proliferation promoting effects on NPCs. (a) SA-β-Gal staining assay of the NPCs induced by USCconMATN3-exos, USCshMATN3-exos, and PBS. (b) SA-β-Gal staining assay showing the antisenescence effect of USC-exos. Multifield random counting showed that the proportion of SA-β-Gal-positive NPCs in USCconMATN3-exos and USCshMATN3-exos groups was significantly lower than that in the control group. (c) CCK-8 analysis of NPCs proliferation stimulated with USCconMATN3-exos, USCshMATN3-exos, and PBS ( per group, vs. control, # vs. USCshMATN3-exos).
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