Bmal1 Regulates the Redox Rhythm of HSPB1, and Homooxidized HSPB1 Attenuates the Oxidative Stress Injury of Cardiomyocytes

Figure 6

Schematic illustrating the working principle of the time rhythm of HSPB1 redox on oxidative stress injury. We propose that Bmal1 maintained the oxidized state of HSPB1, thereby promoting the antioxidant function of HSPB1. Additionally, homooxidized HSPB1 might increase the Nrf-2 nuclear localization, thereby driving the transcription of genes associated with cytoprotection. Ox-HSPB1: homooxidized HSPB1.