Antioxidant Barrier and Oxidative Damage to Proteins, Lipids, and DNA/RNA in Adrenal Tumor Patients

Table 2

Area under the curve (AUC) of malondialdehyde (MDA) and DNA/RNA oxidation products between the controls and incidentaloma and pheochromocytoma, as well as Cushing’s/Conn’s adenoma patients, pheochromocytoma and incidentaloma patient, pheochromocytoma and Cushing’s/Conn’s adenoma patients, incidentaloma and Cushing’s/Conn’s adenoma patients.

	AUC	95% CI	value	Cutoff	Sensitivity %	95% CI	Specificity %	95% CI
Controls vs. incidentaloma
MDA	0.8594	0.7856 to 0.9333	<0.0001	> 135.2	76.67	59.07% to 88.21%	75	62.77% to 84.22%
DNA/RNA oxidation products	0.7694	0.6535 to 0.8853	<0.0001	> 1.255	73.33	55.55% to 85.82%	71.67	59.23% to 81.49%
Controls vs. pheochromocytoma
MDA	0.99	0.9732 to 1.000	<0.0001	> 180.2	95	76.39% to 99.74%	96.67	88.64% to 99.41%
DNA/RNA oxidation products	0.9908	0.9765 to 1.000	<0.0001	> 1.587	95	76.39% to 99.74%	95	86.30% to 98.64%
Controls vs. Cushing’s/Conn’s adenoma
MDA	0.8483	0.7636 to 0.933	<0.0001	> 136.7	75	53.13% to 88.81%	76.67	64.56% to 85.56%
DNA/RNA oxidation products	0.6842	0.5380 to 0.8303	0.0141	> 1.185	60	38.66% to 78.12%	58.33	45.73% to 69.94%
Pheochromocytoma vs. incidentaloma
MDA	0.8467	0.7400 to 0.9533	<0.0001	> 201.2	75	53.13% to 88.81%	76.67	59.07% to 88.21%
DNA/RNA oxidation products	0.825	0.7079 to 0.9421	0.0001	> 1.927	75	53.13% to 88.81%	76.67	59.07% to 88.21%
Pheochromocytoma vs. Cushing’s/Conn’s adenoma
MDA	0.8325	0.6923 to 0.9727	0.0003	< 201.2	75	53.13% to 88.81%	75	53.13% to 88.81%
DNA/RNA oxidation products	0.9025	0.8086 to 0.9964	<0.0001	< 1.752	80	58.40% to 91.93%	80	58.40% to 91.93%
Incidentaloma vs. Cushig’s/Conn’s adenoma
MDA	0.525	0.3575 to 0.6925	0.7664	< 161.7	55	34.21% to 74.18%	53.33	36.14% to 69.77%
DNA/RNA oxidation products	0.5983	0.4371 to 0.7596	0.2427	< 1.471	55	34.21% to 74.18%	56.67	39.20% to 72.62%