Nicotinamide Riboside Alleviates Cardiac Dysfunction and Remodeling in Pressure Overload Cardiac Hypertrophy

Figure 1

NR attenuates the myocardial hypertrophy markers in TAC mice. (a) Narrowed aorta (red arrow) in the TAC group. (b) The HW/BW ratio in the TAC+NR group was significantly reduced compared with the TAC group ( vs. , ). (c) NR reduced TAC-induced LW/BW ratio augmentation ( vs. , ). (d) NR significantly reduced ANP and BNP in TAC mice (ANP: vs. , ; BNP: vs. , ). (e) NR treatment reduced LDH level in hypertrophied mice ( vs.  U/L, ). TAC: transverse aortic constriction; HW/BW: heart/body mass ratio; LW/BW: lung/body mass ratio. vs. sham group; ^# vs. TAC group.

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