Nicotinamide Riboside Alleviates Cardiac Dysfunction and Remodeling in Pressure Overload Cardiac Hypertrophy

Figure 5

NR regulates the NAD⁺-Sirtuin-MnSOD axis. (a) The NAD⁺ content was reduced in TAC grouped myocardium, while NR significantly elevated the NAD⁺ content in the TAC+NR group (). (b) NR treatment can significantly increase the activity of Sirtuin3 protein in the TAC+NR group (). (c) Western blot results show decreased Sirtuin3 expression in the TAC and TAC+NR groups (). The acMOD protein level in the myocardial tissue of mice was significantly increased in the TAC group, while NR treatment can significantly reduce the acMOD protein level (). vs. sham group; ^# vs. TAC group; ^& vs. sham+NR group.

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