Methionine Protects Mammary Cells against Oxidative Stress through Producing S-Adenosylmethionine to Maintain mTORC1 Signaling Activity

Figure 1

Metabolites and mTORC1 signaling in developing mammary glands at different pregnancy day. (a) The H&E stain of mammary glands at different pregnancy day. (b) Composition of mammary glands at different pregnancy day. (c) Clustering result of statistically significant metabolites shown as heat map. Distance measure using euclidean, and clustering algorithm using ward.D. (d) Hydrogen peroxide concentrations in mammary dialysis fluid and tissues. (e) The mTORC1 signaling in pregnant mammary glands. (f) Correlation heat map of statistically significant metabolites. Person’s correlation was concerned in calculation. Strong correlation: 0.66-1, medium correlation: 0.33-0.66, weak correlation: 0-0.33. (g) The concentrations of S-adenosyl-L-methionine (SAM) and S-Adenosyl-L-homocysteine (SAH) in mammary glands. Values were means with SE. , , .

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