Methionine Protects Mammary Cells against Oxidative Stress through Producing S-Adenosylmethionine to Maintain mTORC1 Signaling Activity

<div>Methionine alleviated oxidative stress through SAM-activated mTORC1 independently of transmethylation. (a) Methyltransferase inhibitors mitigated H<sub>2</sub>O<sub>2</sub>-induced inhibition of p-S6K1 (T389). (b) <i>S</i>-adenosylmethionine alleviated H<sub>2</sub>O<sub>2</sub>-induced autophagy through mTORC1 signaling. SAMe: ademetionine 1,4-butanedisulfonate. 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Oxidative Medicine and Cellular Longevity

fig6

Figure 6

Figure 6: Methionine Protects Mammary Cells against Oxidative Stress through Producing S-Adenosylmethionine to Maintain mTORC1 Signaling Activity 