Pharmic Activation of PKG2 Alleviates Diabetes-Induced Osteoblast Dysfunction by Suppressing PLCβ1-Ca²⁺-Mediated Endoplasmic Reticulum Stress

Figure 5

Quantitative proteomics analysis of differentially-expressed proteins regulated by cinaciguat in osteoblasts under T2DM condition. (a) Hierarchical clustering of the differentially expressed proteins. (b) Volcano plots of protein expression profiles. Red/green symbols classified the upregulated/downregulated proteins. (c) Protein-protein interaction was constructed by STRING platform, and the network was visualized in cytoscape. The thick lines represent strong association among proteins. (d) The protein levels of PLCβ1 and IP3R were detected by western blotting to verify the protein mass spectrometry result. Cina: cinaciguat.

(a)

(b)

(c)

(d)