Exploring the Role and Mechanism of pAMPKα-Mediated Dysregulation of Brf1 and RNA Pol III Genes

Table 2

Effect of factors on overall survival in lung cancer patients in the univariate and multivariate Cox regression model.

Factors	Univariate		Multivariate^,†,‡
	HR (95% CI)		HR (95% CI)
Age (<48/≥48)	2.69 (0.85-8.49)	0.091	—	—
Gender (male/female)	1.34 (0.85-2.12)	0.206	—	—
Differentiation (poor/well, moderate)	1.12 (0.76-1.65)	0.563	—	—
Lymph node invasion (present/absent)	0.49 (0.33-0.71)	0.000	—	—
Clinical stage (III-IV/I-II)	2.85 (1.92-4.22)	0.000	2.71 (1.82-4.02)	0.000
Brf1 (high/low)	0.55 (0.36-0.84)	0.006	0.60 (0.39-0.93)	0.021

Hazard ratios and values were obtained from Cox proportional hazards regression. All statistical tests were two-sided. ^†For the multivariate model, HR and values were shown for the final set of stepwise selected variables only. ^‡The parameters with value less than 0.05 in the univariate were included in the multivariate Cox analysis using SPSS 20.0.