Using Genomic and Transcriptome Analyses to Identify the Role of the Oxidative Stress Pathway in Renal Clear Cell Carcinoma and Its Potential Therapeutic Significance

Figure 4

(a, b) Heatmap showing GSEA analysis of the enriched gene sets among the three clusters. The rows and columns are defined by using different gene sets based on GO analysis and three clusters successively. Cluster1, Cluster2, and Cluster3 are represented by green, red, and blue successively. Two figures have been used to show the results based on the regulation of the pathway, indicating upregulation and downregulation. Classical cancer pathway genes (c); sirtuin family genes (d); HDAC family genes (e); the expression of both in KIRC is shown using the heatmap (, , , and ). Blue represents Cluster1, red represents Cluster2, and green represents Cluster3. The color bar on the right indicates that warm colors represent high gene expression, while cool colors represent low gene expression (red to blue).

(a)

(b)

(c)

(d)

(e)