Using Genomic and Transcriptome Analyses to Identify the Role of the Oxidative Stress Pathway in Renal Clear Cell Carcinoma and Its Potential Therapeutic Significance

Figure 6

(a) Heatmap showing the correlation between the immune infiltration and the OS-related genes. The level of correlation is represented with colors; red represents positive correlation, and blue represents negative correlation (, ). (b) The plot shows the degree of correlation, the area of the circle represents the abs (correlation), and the color bar on the right side shows the value. (c, d) APC-costimulation and macrophages were selected, and a scatter diagram has been used to show the correlation with OS score (OS score). (e) The plot shows the correlation analysis of PD-1, CTLA-4, and OS score. The scatter diagram and color bar represent the correlation and coefficient, respectively. (f) Submap analysis shows that the OS-inactive cluster could be more sensitive to cytotoxic T lymphocyte-associated protein 4 (CTLA-4) inhibitor (nominal value = 0.01). However, data obtained after the Bonferroni correction indicated that it was not significantly different ( value is represented by the color block; purple indicates high values and yellow indicates low values).

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